Combination of Proton Pump Inhibitors, Other Drugs, May Increase Kidney Risks

Published on September 26, 2016 by Sandy Liebhard

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Several recent studies have suggested that proton pump inhibitors may increase an individual’s risk for kidney failure and other renal complications. Now a new study has indicated  that patients who use these heart burn drugs  along with other medications known to impair renal function may face an even greater risk of developing a potentially dangerous kidney injury called acute interstitial nephritis,

In 2014, the U.S. Food & Drug Administration (FDA) asked the manufacturers of all prescription proton pump inhibitors to include mention of acute interstitial nephritis on their product labels. The condition, which is characterized by a sudden inflammation of the kidney tubules, is generally the result of an allergic reaction to a drug. If not recognized and treated in a timely manner, acute interstitial nephritis can progress to chronic kidney disease and renal failure.

Study Findings

For this latest study published in the International Journal of Basic & Clinical Pharmacology, researchers administered Prilosec, Protonix and Aciphex to three groups of lab rats over a 28-day period. The first group received only a proton pump inhibitor, while the second received a heartburn drug along with a pain relieving medication called diclofenac. The third group received ofloxacin in addition to the proton pump inhibitor.

At the end of 28 days, the research team observed that:

  • Rats who received only Prilosec showed no signs of acute interstitial nephritis.
  • Those that received Prilosec and diclofenac developed acute interstitial nephritis, and exhibited structural changes and vascular damage that could progress to acute kidney failure.
  • Similar structural changes and vascular damage was seen in rats treated solely with high doses of Aciphex.
  • Those that received both Aciphex and the other drugs had an increased rate of acute interstitial nephritis.
  • Rats that received low, medium or high doses of Protonix all presented with structural changes that could lead to kidney failure, as well as interactions with the other medications.

“PPI alone are prone to cause AIN but the incidence of AIN is increases with addition of other nephrotoxic dugs,” the authors of the report concluded.

Proton Pump Inhibitor Litigation

A number of lawsuits have been filed in recent months involving proton pump inhibitors and kidney injuries. Just last month, the nationwide law firm of Bernstein Liebhard LLP filed a Nexium lawsuit in New York federal court on behalf of an Ohio man who was diagnosed with chronic kidney disease following treatment with that medication.

The Firm continues to offer free legal reviews to individuals who may have suffered kidney complications allegedly related to the use of both prescription and over-the-counter proton pump inhibitors. To learn more, please call (888) 988-0035,

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