Several recent studies have suggested that proton pump inhibitors may increase an individual’s risk for kidney failure and other renal complications. Now a new study has indicated that patients who use these heart burn drugs along with other medications known to impair renal function may face an even greater risk of developing a potentially dangerous kidney injury called acute interstitial nephritis,
In 2014, the U.S. Food & Drug Administration (FDA) asked the manufacturers of all prescription proton pump inhibitors to include mention of acute interstitial nephritis on their product labels. The condition, which is characterized by a sudden inflammation of the kidney tubules, is generally the result of an allergic reaction to a drug. If not recognized and treated in a timely manner, acute interstitial nephritis can progress to chronic kidney disease and renal failure.
For this latest study published in the International Journal of Basic & Clinical Pharmacology, researchers administered Prilosec, Protonix and Aciphex to three groups of lab rats over a 28-day period. The first group received only a proton pump inhibitor, while the second received a heartburn drug along with a pain relieving medication called diclofenac. The third group received ofloxacin in addition to the proton pump inhibitor.
At the end of 28 days, the research team observed that:
“PPI alone are prone to cause AIN but the incidence of AIN is increases with addition of other nephrotoxic dugs,” the authors of the report concluded.
A number of lawsuits have been filed in recent months involving proton pump inhibitors and kidney injuries. Just last month, the nationwide law firm of Bernstein Liebhard LLP filed a Nexium lawsuit in New York federal court on behalf of an Ohio man who was diagnosed with chronic kidney disease following treatment with that medication.
The Firm continues to offer free legal reviews to individuals who may have suffered kidney complications allegedly related to the use of both prescription and over-the-counter proton pump inhibitors. To learn more, please call (888) 988-0035,